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KMID : 1040120140050010085
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Evidence and Values in Healthcare
2014 Volume.5 No. 1 p.85 ~ p.95
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Kim Youn-Hee
Park Joo-Yeon
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Abstract
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This study was conducted to evaluate the efficacy and cost-effe ctiveness of raloxifene in osteopenia patients with high fracture risk. W e searched for and reviewed the relevant published systematic reviews, randomi zed clinical trials(RCTs), and economic evaluation studies. The search results showed that there were no systematic reviews that explored the efficacy of raloxifene in osteopenia patients with high fracture risk. Only one RCT and one co st-effectiveness analysis were reviewed. In the RCT, raloxifene significantly re duced the risk of vertebral fractures and clinical vertebral fractures as compared to the placebo in patients with osteopenia. In addition, raloxifene was cost-effe ctive for women who were between 55 and 60 years of age and had osteopenia, but not cost-effective for women 65 years or older. In conclusion, the evidence of efficacy and costeffectiveness was limited to treatment with raloxifene for osteopenia patients with high fracture risk.
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KEYWORD
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